Education Background:
Master of Science in Dental Sciences, Faculty of Dental Medicine and Oral Health Sciences, McGill University (2020)
Bachelor of Science in Biochemistry, Minor in German Language, McGill University (2017)
Favourite Lab Equipment:
That vintage computer from early 2000
“I will never do a Ph.D.”
Research Project and Interests:
Extracellular vesicles as biologically derived drug delivery vectors are gaining considerable interest in the field of nanomedicine. These membrane-bound structures are secreted by almost all types of cells and play important roles in cellular communication and numerous physiological and pathological processes. I am particularly interested in mesenchymal stem cells derived extracellular vesicles and their biomimetics, often termed nanoghosts, due to their reported innate immunomodulatory, anti-inflammatory, and regenerative properties. My Ph.D. project focuses on harnessing these desirable properties while further engineering nanovesicles from stem cells towards targeted gene delivery for attenuating the pathogenesis of osteoarthritis.
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Fonds de Recherche du Quebec Sante (FRQS) Doctoral Scholarship (2024)
Faculty of Dental Medicine and Oral Health Sciences Graduate Research Enhancement and Travel Award (2022, 2020)
Dr. Doreen E. Laszlo Graduate Felowship (2021, 2019)
1st Place Oral Presentation - 15th Annual McGill Faculty of Dental Medicine and Oral Health Sciences Research Day (2021)
RSBO Student Conference Award (2020)
Dr. Lyon Bercovitch Memorial Award (2019)
Faculty of Dental Medicine and Oral Health Sciences Mineralized Tissue Studentship (2019)
Graduate Excellence Award (2018)
McGill Integrated Cancer Research Training Program Studentship (2017)
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Peer-Reviewed Articles:
A. Karoichan, S. Boucenna, M. Tabrizian* (2024), “Therapeutics of the future: navigating the pitfalls of extracellular vesicles research from an osteoarthritis perspective”, J. Extracellular Vesicles, JEXV-2024-01-0060.
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q.-L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty, S., Möller, A., Nieuwland, R., … Witwer, K. W. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. Journal of Extracellular Vesicles, 13, e12404. https://doi.org/10.1002/jev2.12404
Agnes, C.J., Karoichan, A., and Tabrizian, M. “The Diamond Concept Enigma: Recent Trends of its Implementation in Crosslinked Chitosan-Based Scaffolds for Bone Tissue Engineering.” ACS Applied Biomaterials. 6:7, 71-82. 2023
Karoichan, A., Baudequin, T., Al-Jallad, H., & Tabrizian, M. (2022). Encapsulation and differentiation of adipose-derived mesenchymal stem cells in a biomimetic purine cross-linked chitosan sponge. Journal of Biomedical Materials Research Part A, 110( 3), 585– 594. https://doi.org/10.1002/jbm.a.37311
Peer-Reviewed Abstracts
Karoichan A, Tabrizian M. MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLE MIMETICS AS OSTEOINDUCTIVE MEDIATORS: AN IN VITRO INVESTIGATION. Orthop Procs. 2024;106-B(SUPP_1):34-34. doi:10.1302/1358-992X.2024.1.034
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Conferences:
A. Karoichan, C. J. Agnes, L. Li, B. M. Willie, M. Tabrizian, “Mesenchymal Stem Cell-Derived Extracellular Vesicles Mimetics for Enhanced Bone Healing and Regeneration”, The Annual Meeting and Exposition of the Controlled Release Society 2024, July 8-12, 2024, Bologna, Italy
C. J. Agnes, L. Li, D. Bertrand, A. Karoichan, M. Murshed, B. M. Willie, M. Tabrizian, “Encapsulation of Glycogen Synthase Kinase 3 Beta (GSK3B) Phosphorylation Inhibitor, 6-Bromo-Indirubin-3’-Oxime, in a Chitosan Based Scaffold for the Treatment of Critical Size Bone Defects”, Orthopaedic Research Society 2024 Annual Meeting, February 2-6, 2024, Long Beach, USA
A. Karoichan, C. J. Agnes, L. Li, B. M. Willie, M. Tabrizian, “Mesenchymal Stem Cell-Derived Extracellular Vesicles Mimetics for Enhanced Bone Healing and Regeneration”, The 18th Annual McGill Faculty of Dental Medicine and Oral Health Sciences Research Day, April 24, 2024, Montreal, Canada
A. Karoichan, M. Tabrizian, “Mesenchymal Stem Cells-Derived Extracellular Vesicle Mimetics as Osteoinductive Mediators: An In Vitro Investigation”, The 31st Annual Meeting of the European Orthopaedic Research Society, September 27-29, 2023, Porto, Portugal
A. Karoichan, M. Tabrizian, “Mesenchymal Stem Stem Cell-Derived Extracellular Vesicles and Nanoghosts: An In Vitro Comparison of their Osteoinductive Properties”, The 17th Annual McGill Faculty of Dental Medicine and Oral Health Sciences Research Day, April 18, 2023, Montreal, Canada
A. Karoichan, M. Tabrizian, “Mesenchymal Stem Stem Cell-Derived Extracellular Vesicles and Nanoghosts: An In Vitro Comparison of their Osteoinductive Properties”, May 10, 2023, Montreal, Canada
Karoichan, A., Tabrizian, M. (2022). RGD-integrin interactions as a facile approach to tether ligands onto the surface of extracellular vesicles for targeted drug delivery applications. 32nd Annual Conference of the European Society for Biomaterials. Bordeaux, France (poster presentation)
Karoichan, A., Baudequin, T., Al-Jallad, H., & Tabrizian, M. (2022). Encapsulation and Osteogenic Differentiation of Mesenchymal Stem Cells in a Biomimetic, Purine Cross-Linked Chitosan Sponge for Bone Tissue Engineering. 2022 US Society for Biomaterials (SFB) and Japanese Society of Biomaterials (JSB) Joint Symposium. Honolulu, Hawaii, USA (poster presentation)
Karoichan, A., Baudequin, T., Al-Jallad, H., & Tabrizian, M. (2021). Encapsulation and Osteogenic Differentiation of Mesenchymal Stem Cells in a Biomimetic, Purine Cross-Linked Chitosan Sponge for Bone Tissue Engineering. 15th Annual McGill Faculty of Dental Medicine and Oral Health Sciences Research Day. Montreal, Quebec, Canada (oral presentation)
Karoichan, A., Baudequin, T., Al-Jallad, H., & Tabrizian, M. (2021). Encapsulation and Osteogenic Differentiation of Mesenchymal Stem Cells in a Biomimetic, Purine Cross-Linked Chitosan Sponge for Bone Tissue Engineering. 5th Annual Biological and Biomedical Engineering Symposium. Montreal, Quebec, Canada (poster presentation)
Karoichan, A., Baudequin, T., Al-Jallad, H., & Tabrizian, M. (2021). Encapsulation and Osteogenic Differentiation of Mesenchymal Stem Cells in a Biomimetic, Purine Cross-Linked Chitosan Sponge for Bone Tissue Engineering. RSBO Virtual Scientific Research Days. Montreal, Quebec, Canada (poster presentation)
Karoichan, A., Baudequin, T., Al-Jallad, H., & Tabrizian, M. (2020). Encapsulation and Differentiation of Adipose Derived Stem Cells in a Rapidly-Gelling Chitosan Sponge for Interfacial Tissue Regeneration: Optimization of Parameters. 11th World Biomaterials Congress. Glasgow, Scotland, UK (poster presentation)
Invited Lecturer:
McGill University BMDE/DENT 504 - Biomaterials and Bioperformance. (2023). Biological characterization of biomaterials: Part I (Hard Tissues)
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Master’s Research Project (2018-2020)
Biomat’X Research Laboratories
”Guanosine Diphosphate Cross-Linked Chitosan Sponge for the Encapsulation and Differentiation of Adipose-Derived Mesenchymal Stem Cells”
I worked on investigating the potential of encapsulating and promoting the differentiation of mesenchymal stem cells inside the GDP cross-linked chitosan sponge previously developed by the Biomat’X group.Research Assistant (2016-2018)
Rosalind & Morris Goodman Cancer Institute - McGill University
Teodoro Lab
I worked on using the CRISPR/Cas9 technology to introduce a point mutation in the gene CrkRS in order to investigate its effects and possible implication in nephroblastoma development. I was also involved in inducing granulocytic differentiation of NB4 cells and studying the effects on gene expression. -
VP Academic Events, RSBO AGORA group (January 2021 to Present)
VP Communications, McGill Dentistry Graduate Students’ Society (September 2018 – September 2019)